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Effective evaluation of benzydamine hydrochloride as a mouth wash in subjects with plaque induced gingival inflammation
- Author Details:
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Hema Seshan
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Sheza Shanavas
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Ashwini S
Purpose: Benzydamine hydrochloride is a nonsteroidal anti-inflammatory drug that has shown topical anti-inflammatory, analgesic, anesthetic, and antimicrobial activities most often used in radiation induced oral mucositis. The aim of this study was to assess the effectiveness of 0.15% benzydamine hydrochloride as a mouth wash in subjects with severe generalized gingivitis on comparison with 0.2% chlorhexidine.
Methods: In this double-blind, randomized, clinical trial, 30 patients were equally divided into two groups. Patients in Group I were advised to rinse their mouths with 10 ml of 0.2% chlorhexidine(CHX) twice daily, Group II with 10 ml of benzydamine (BZD) mouth wash twice daily for two weeks. The clinical parameters measured were plaque index (PI), gingival index (GI), modified sulcular bleeding index (mSBI). These parameters were recorded at baseline, I week, 2 weeks and 1 month.
Results: There was no significant difference when the efficacy of benzydamine hydrochloride was compared to 0.2% chlorhexidine in subjects with severe gingivitis. A statistically significant decrease was observed in PI, GI, mSBI scores at 1 week, 2 weeks and 1 month when compared to baseline (P<0.05) in both the groups although intergroup comparison did not reveal statistical significant difference between the test and the control group. (P>0.05)
Conclusions: Benzydamine hydrochloride 0.15% as a mouth wash was as effective as chlorhexidine digluconate 0.2% in reducing gingival inflammation induced due to plaque accumulation thus, controls further disease progression. This chemical agent is also cost effective, easily available, and well tolerated with no reported side effects.
Keywords: Benzydamine, Chlorhexidine, Gingival Inflammation, Mouth Wash, NSAID, Periodontal disease
References
- Perry DA. Plaque control for the periodontal patient. In: Newman MG, Takei HH, Klokkevold PR, Carranza FA, Editor. Carranza's Clinical Periodontology. 10 th ed. St. Louis, Missouri: Saunders; 2006. p. 728.
- Mandel ID. Antimicrobial mouthrinses: Overview and update. J Am Dent Assoc 1994;125(Suppl 2):2S-10.
- Kayalvizhi G, Suganya G, Balaji Subramaniyan R. A Cuppa for Caries Free Teeth? International Journal Contemporary Medical Research 2014;1:19-27.
- Zanatta FB, Antoniazzi RP, Rosing CK. The effect of
- 12% chlorhexidine gluconate rinsing on previously plaque-free and plaque-covered surfaces: A randomized, controlled clinical trial. J Periodontol 2007;78:2127-34.
- Gupta D, Bhaskar DJ, Gupta RK, Karim B, Gupta V, Punia H, et al. Effect of Terminalia chebula extract and chlorhexidine on salivary pH and periodontal health: 2 weeks randomized control trial. Phytotherapy Research 2014;287:992-8.
- Gupta D, Bhaskar DJ, Gupta RK. Contemporary and alternative dentistry: Ayurveda in dentistry. Germany, Lap Lambert Academic Publishing; 2013.
- Cheng K. Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis. European Journal of Oncology Nursing. 2004;8(4):341–9.
- Epstein JB, Stevenson-Moore P, Jackson S, Mohamed JH, Spinelli JJ. Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse. International Journal of Radiation Oncology* Biology* Physics. 1989;16(6):1571–5.
- Kim J, Chu F, Lakshmi V, Houde R. Benzydamine HCl, a new agent for the treatment of radiation mucositis of the oropharynx. American journal of clinical oncology. 1986;9(2):132–4.
- Prada A, Chiesa F. Effects of benzydamine on the oral mucositis during antineoplastic radiotherapy and/or intra- arterial chemotherapy. Int J Tissue React 1987;9:115–9.
- Samaranayake LP, Robertson AG, MacFarlane TW, Hunter IP, MacFarlane G, Soutar DS, et al. The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clin Radiol 1988;39:291–4.
- O'Sullivan B, Kroll B. Benzydamine hydrochloride for symptomatic relief of radiation mucositis in the treatment of advanced larynx cancer. In: Dick WC, Bowsher DR, editors. Benzydamine: a topical NSAID. Res Clin Forums 1988;10:83–9.
- Sonis ST, Clairmont F, Lockhart PB, Connolly SF. Benzydamine HCl in the management of chemotherapy- induced mucositis. J Oral Med 1985.
- Sironi MK, Pozzi P, Polentarutti N, Benigni F, Coletta I, Guglielmotti A, et al. Inhibition of inflammatory cytokine production and protection against endotoxin toxicity by benzydamine. Cytokine 1996;8:710–6.
- Sironi M, Milanese C, Vecchi A, Polenzani L, Guglielmotti A, Coletta I, et al. Benzydamine inhibits the release of tumor necrosis factor-alpha and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells. Int J Clin Lab Res 1997;27:118–22.
- Guglielmotti A, Aquilini L, Rosignoli MT, Landolfi C, Soldo L, Coletta I, et al. Benzydamine protection in a mouse model of endotoxemia. Inflamm Res 1997;46:332–
- Roopashri G, Jayanthi K, Guruprasad R. Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail. Contemporary clinical dentistry. 2011 Jan 1;2(1):8.
- Kazemian A, Kamian S, Aghili M, Hashemi FA, Haddad P. Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebocontrolled randomized clinical trial. Eur J Cancer Care 2009;18:174–178.
- Epstein JB, Silverman S Jr, Paggiarino DA, Crockett S, Schubert et al. Benzydamine hcl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial. Cancer. 2001;92(4):875–885.
- Nicolatou-Galitis O, Sarri T, Bowen J, Di Palma M, Kouloulias et al. Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients. Support Care Cancer 2013.21(11):3179–3189.
- Silness J, Loe H. Periodontal disease in pregnancy: II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-128.
- Loe H, Silness J. Periodontal disease in pregnancy: I. Prevalence and severity. Acta Odontol Scand 1963;21:533-541.
- The Muhlemann-Son Sulcus Bleeding Index--its evaluation as a practice-relevant method for early recognition of periodontopathies using comparative measurements of the partial pressure of oxygen in the capillaries of the gingiva. Stomatol DDR. 1983 May;33(5):342-8.
- Marc Quirynen, Catherine Soers, Mandy Desnyder, Christel Dekeyser, Martine Pauwels, Daniel Van Steenberghe A 0.05% cetyl pyridinium chloride/0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy Journal of clinical periodontology, Volume 32, Issue 4, April 2005;390–400.
- Herrera, D., Rolda´n, S., Santacruz, I., Santos, S., Masdevall, M. & Sanz, M. Differences in antimicrobial activity of four commercial 0.12% chlorhexidine mouthrinse formulations: an in vitro contact test and salivary bacterial counts study. Journal of Clinical Periodontology 2003;307–314.
- Addy, M. & Moran, J. M. Evaluation of oral hygiene products: science is true; don't be misled by the facts. Periodontology 2000,1997;15,40–51.
- Putwatana P, Sanmanowong P, Oonprasertpong L, Junda T, Pitiporn S, Narkwong L. Relief of radiation-induced Hema Seshan et al. Effective evaluation of benzydamine hydrochloride as a mouth wash in subjects…. International Journal of Oral Health Dentistry; July-September 2016;2(3):161-170 170 oral mucositis in head and neck cancer. Cancer Nurs 2009;32:82–7.
- Samaranayake LP, Robertson AG, MacFarlane TW, Hunter IP, MacFarlane et al. The effect of chlorhexidine and benzydamine mouthwashes on mucositis induced by therapeutic irradiation. Clin Radiol 1988;39:291–300.
- Worthington HV, Clarkson JE, Eden O. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev
- 4:CD000978.
- Clarkson J, Worthington H, Eden O. Interventions for preventing oral candidiasis for patients with cancer receiving treatment. Cochrane Database Syst Rev
- 2:CD001973.
- Clarkson JE, Worthington H, Eden O. Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev ,
- 8:CD001973.
- Kamian S, Kazemian A, Amouzegar Hashemi F, Aghili M et al. Benzydamine for prophylaxis of radiation induced oral mucositis in head and neck cancers, double blind clinical trial. Eur J Cancer Suppl 2007;5:339.
- Mody RN, Talukdar S. Efficacy of Benzydamine hydrochloride oral rinses in Radiation mucositis. J Indian Dent Assoc 1993;64:93-7.
- Cheng KK, Chang AM. Palliation of oral mucositis symptoms in pediatric patients treated with cancer chemotherapy. Cancer nursing. 2003;26(6):476–84.
- Cheng KK, Chang AM, Yuen M. Prevention of oral mucositis in paediatric patients treated with chemotherapy: a randomised crossover trial comparing two protocols of oral care. European Journal of Cancer. 2004;40(8):1208–
- Wesley SJ. Clinical evaluation of subgingival irrigation with chlorhexidine and benzydamine in periodontitis. International Journal of Dental Clinics. 2014;6(4):11-13.
- Wesley SJ. Microbial Evaluation of a Single Subgingival Irrigation with Chlorhexidine and Benzydamine in Advanced Periodontitis. World. 2014;5(1):37-41.
- Cingi C, Songu M, Ural A, Erdogmus N, Yildirim M, Cakli H, et al. Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, double-blinded, placebo-controlled study. The Journal of Laryngology & Otology. 2011;125(06):620-5.
- Fanaki, N. H. & El Nakeeb, M. A. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. Journal of Chemotherapy 1992;347–352.
- Santos A. Evidence-based control of plaque and gingivitis. J Clin Periodontol 2003;30 Suppl 5:13-6.
How to Cite This Article
Vancouver
Seshan H, Shanavas S, S A. Effective evaluation of benzydamine hydrochloride as a mouth wash in subjects with plaque induced gingival inflammation [Internet]. Int J Oral Health Dent. 2016 [cited 2025 Oct 19];2(3):161-170. Available from: https://doi.org/
APA
Seshan, H., Shanavas, S., S, A. (2016). Effective evaluation of benzydamine hydrochloride as a mouth wash in subjects with plaque induced gingival inflammation. Int J Oral Health Dent, 2(3), 161-170. https://doi.org/
MLA
Seshan, Hema, Shanavas, Sheza, S, Ashwini. "Effective evaluation of benzydamine hydrochloride as a mouth wash in subjects with plaque induced gingival inflammation." Int J Oral Health Dent, vol. 2, no. 3, 2016, pp. 161-170. https://doi.org/
Chicago
Seshan, H., Shanavas, S., S, A.. "Effective evaluation of benzydamine hydrochloride as a mouth wash in subjects with plaque induced gingival inflammation." Int J Oral Health Dent 2, no. 3 (2016): 161-170. https://doi.org/