Polymerase chain reaction (PCR) – A review with its pertinency to dentistry

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Review Article

Author Details : Sumit Kumar Yadav, Achla Bharti Yadav*, Neal Bharat Kedia, Gunjan Kedia, Kunal Kumar

Volume : 5, Issue : 4, Year : 2019

Article Page : 184-190

https://doi.org/10.18231/j.ijohd.2019.042

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Abstract

Advances in molecular technologies over recent years have a profound impact on diagnostic pathology. These techniques utilize DNA, RNA and enzymes that interact with nucleic acids to understand biology at a molecular level. They will also provide a complementary approach to traditional methods of histopathological analysis in the future. Various molecular techniques are now being widely used throughout the world including polymerase chain reaction (PCR), hybridization methods, flow cytometry, tissue microarray and laser capture microdissection (LCM). Among these PCR is one of the most common diagnostic modality with high specificity, sensitivity and variety of applications. It will significantly impact three major areas: specific diagnosis, prognosis determination and prediction of response to therapy. Therefore, it has a great potential to become a standard procedure in diagnostic surgical pathology. The application of PCR in the context of dentistry is also presented here, along with the basics of PCR and its fundamental aspects.

Keywords: Applications, Dentistry, Inhibitors, Oral cancer, Polymerase Chain reaction, Tumor biology.

How to cite : Yadav S K, Yadav A B, Kedia N B, Kedia G, Kumar K, Polymerase chain reaction (PCR) – A review with its pertinency to dentistry. Int J Oral Health Dent 2019;5(4):184-190

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