Neurofibromatosis Type 1 (NF1) is a genetic disorder characterized by multisystem involvement, including neurocutaneous manifestations, skeletal deformities, and orofacial abnormalities. This case report presents a 35-year-old male with NF1, exhibiting multiple café-au-lait macules, skeletal abnormalities, and significant radiographic findings affecting the mandible. The patient was completely edentulous with a constricted maxillary arch and a broad mandibular arch, leading to a Class III jaw relation. Prosthodontic rehabilitation was undertaken using a cross-arch teeth arrangement to achieve occlusal stability and functional efficiency. This report underscores the significance of a multidisciplinary approach in the management of patients with Neurofibromatosis Type 1 (NF1), with particular attention to the contribution of prosthodontic interventions in addressing skeletal irregularities. The use of a cross-arch configuration demonstrated success in reestablishing occlusal balance, even in the presence of anatomical complexities. Looking ahead, developments in digital occlusal assessment and the application of implant-supported prosthetics hold promise for improving outcomes in similarly challenging cases.
